In the movie, which was Julia Roberts' breakout film, he was billed under his full name Vincent Phillip D'Onofrio.
D'Onofrio continued to play a wide variety of minor or supporting roles, including the father of a saint in Nancy Savoca's Household Saints (1993), director Orson Welles in Tim Burton's Ed Wood (1994), farmer Edgar and the evil "Bug" that possesses him from Men in Black (1997), Yippie founder Abbie Hoffman in Steal This Movie!
While filming an obstacle course scene for the movie, D'Onofrio injured his left knee, compounded by the excessive weight, which required surgical reconstruction.
Robert Goren in Law & Order: Criminal Intent, Edgar/the Bug in Men in Black (1997), and Vic Hoskins in Jurassic World (2015). She was followed by Elizabeth (1957), now an actress and drama coach residing in Fort Myers Beach, Florida, then by Vincent.
Sharkansas Women's Prison Massacre (TV Movie) (performer: "Sparks Will Fly Tonight", "Better Than Techno" - as Vincent S.
D'Onofrio) / (writer: "Sparks Will Fly Tonight", "Better Than Techno" - as Vincent S.
In November 2005, D'Onofrio won Best Actor at the Stockholm International Film Festival for his role as Mike Cobb in the independent film Thumbsucker.
In 2006, he appeared in The Break-Up, starring Jennifer Aniston and Vince Vaughn, playing Vaughn's eccentric brother.On a tip from friend Matthew Modine, D'Onofrio was urged to send audition tapes to director Stanley Kubrick, in England. D'Onofrio gained 70 lb (32 kg) for the role, bringing his weight to 280 lb (130 kg).